PFAS Analysis in Household Dust Using GCxGC-HRT

Comprehensive two-dimensional gas chromatography (GCxGC) paired with high-resolution time-of-flight mass spectrometry (HR-TOFMS) provides a sophisticated approach for investigating the chemical diversity of per- and polyfluoroalkyl substances (PFAS) in indoor dust. By utilizing enhanced chromatographic resolution and accurate mass measurements, this method facilitates the identification of both targeted legacy compounds and emerging neutral PFAS precursors that contribute to human exposure.