Metabolomics Industry Resources
Metabolomics presents challenges from sample introduction to the analytical methods used, and the data reduction required to interpret the results. No single analytical technique can be used for complete characterization of the metabolome, and no metabolome has ever been completely characterized.
Despite these challenges, LECO’s just-in-time derivatizer coupled with the Gas Chromatography Mass Spectrometers (GC-MS) provides an established method to introduce samples into the GC-MS and analyze the primary metabolome, whereas other techniques simply investigate the secondary and tertiary metabolites. One of the principal challenges in metabolomics is the detection and identification of unknowns; you need to know what else is in your sample to successfully characterize it, and our GC-MS solutions give you a clear advantage. Our solutions have a robust automated derivatization and sample introductory method, separation, accuracy, resolving power, deconvolution, and speed to characterize the most complex metabolite profiles.
Instrument Portfolio
GCxGC Time-of-Flight Mass Spectrometer
High Resolution GC-TOFMS
High Resolution GCxGC-TOFMS
Application Notes
Learn more about our solutions for Metabolomics with our library of related application notes.
203-821-422 | Application of GC High Resolution Time-of-Flight Mass Spectrometry to Mouse Liver Metabolomic Analyses Liver disease affects more than 800 million people worldwide causing at least 1.5 million deaths annually. Mice provided a reliable model for detection of polychlorinated biphenyls associated with non-alcoholic fatty liver disease. |
203-821-447 | Enhanced Metabolite Profiling: Hard and Soft Ionization High-Resolution Time-of-Flight Mass Spectrometry |
203-821-377 | Utilization of Statistical Compare Software and Fisher Ratios Prior to Multivariate Analysis for Complex GCxGC-TOFMS Data in Order to Define Statistical Variation Between the Small Molecule Metabolite Profiles of Different Fish Species |
203-821-503 | How Comprehensive is Your Analysis? Human Molecular Profiling Using High Resolution Time-of-Flight Mass Spectrometry |
203-821-504 | Quantitative Analysis of y-Hydroxybutyrate in Hair using Target Analyte Finding Processing of Comprehensive GC-HRT Data |
News or Stories
Learn how Jane Hill is using GCxGC and the study of metabolomics to develop a new method of diagnosing lung infections.
Using GC-GC-TOFMS, Jef Focant is able to diagnose the asthma phenotype in patients.
Videos and Webinars
- 1Mold Metabolites From 17 February 2011
- 2Small Molecule Metabolite Profiling and Characterization From 16 June 2011
- 3High Resolution GCMS Applications in Metabolomics From 21 February 2013
- 4Dramatically Increase Information Content in Metabolomics Studies From 24 October 2013
- 5Science from Beyond the Grave: a Virtual GC Symposium From 31 October 2021
- 6Breath Analysis – Investigating the Human Volatome From 7 February 2022
Posters and Presentations
- Comparative Analysis of Lipophilic Wood Extractives by GCxGC-TOFMS
- Metabolites EI-CI GC-HRT
- Complex Biological Samples Small Metabolite Identifications GCxGC-TOFMS
- Complex Biological Samples Small Metabolite Statistical Compare Fisher Ratios GCxGC-TOFMS
- Volatile Organic Components Human Breath GCxGC-TOFMS Breath analysis is a non-invasive technique for multiple disease biomarkers. High humidity in breath samples provide unique challenges for analysis.
- Complex Biological Mixtures Multi-Reflection Mass Resolution Modes HRT