Software for Separation Science

What ChromaTOF Is

LECO’s ChromaTOF® brand software is an industry standard mass spectrometer data system for acquiring, processing, and reporting data. Uniquely designed to meet the needs of today’s laboratory professionals in the food/flavor/fragrance, metabolomics, environmental, and petrochemical industries. ChromaTOF offers seamless control of both the instrument and accessories, as well as an intuitive acquisition queue with built-in data processing.

  • Processing focuses on both targeted and non-targeted analysis
  • Quantitation includes standard calibration curves, absolute and relative quantitation
  • Qualitative Analysis with True Signal Deconvolution® (ChromaTOF-GC) and High Resolution Deconvolution (ChromaTOF-HRT®) which generates library searchable pure spectra (Peak True)
  • A comparison tool (Reference) experimentally contrasts and identifies differences between two samples
  • All data and processing results are fully reportable and exportable (standard formats)

What Sets ChromaTOF Apart

  • Data processing is automatically saved within file system
  • Data file system stores and manages meta- and instrument data for you.
  • All features contained within one software package.
  • Easy-to-use, efficient, and robust
  • Frequently updated for continuous maintenance and feature development
  • ChromaTOF-HRT’s new and revamped Windows® 7 ribbon-style menu system supports superior mass accuracy from high resolution spectrometry
  • ChromaTOF-GC, used by industry leaders for over 15 years, supports GCxGC deconvolution, visualization, and reporting.



  • True Signal Deconvolution, Automated Peak Find, and Extended Range Calibration algorithms
  • Enhanced graphics for GCxGC users, including the option of displaying peak labels and peak markers on contour and surface plots
  • Importable ready-to-use workspace templates for access to preferred user interfaces and reduced set-up times
  • Semi-Quantitative Analysis for the reporting of non-calibrated compounds
  • Automatic tuning within user-defined quality control methods
  • Integrated control of a variety of sample handling options from Gerstel, LEAP, Shimadzu, and Agilent
  • Fully-integrated optional environmental report designer
  • Customizable user interface
  • Automatically export data to PDF, CSV, ANDI MS, NETCDF, or Raw file formats
  • Compatibility with LECO's consumable-free GCxGC thermal modulator
  • Classification development tools
  • Capacity for files up to 4 GB and compatibility with Windows operating systems
  • The LECO/Fiehn Metabolomics Library features over 1,100 spectra of 700 unique metabolomics for metabolite identification in your most complex samples. Fully integrated within ChromaTOF, the library works seamlessly with the software's Library Search function to automatically identify potential analyte matches without the need for importing or exporting data.
  • To learn more about LECO’s advantages for metabolomics, view the following video presentation, presented by Dr. Oliver Fiehn of UC Davis at Metabolomics 2015: Large Scale Analysis of Primary and Volatile Metabolism by GC-TOFMS


Designed specifically for HRT instrumentation, LECO’s own ChromaTOF-HRT software encapsulates the industry’s most advanced qualitative and quantitative capabilities in one user-friendly data-handling system.

  • Automated Peak Find with High Resolution Deconvolution algorithm
  • Identify known/unknowns with NIST and accurate fragment formula calculations
  • Create and use Accurate Mass Spectral Libraries 
  • User-scalable mass defect plots (eg. Kendrick and Halogen scales)
  • Search for unknown unknowns with ChemSpider
  • Tools to facilitate high-performance MS analysis include formula calculator and spectral annotation
  • Semi-quantitative analysis for the reporting of non-calibrated compounds
  • Fully-integrated optional environmental report designer
  • Automatic tuning capability
  • Integrated control of Agilent 7890GC
  • Customizable user interface
  • Automatically export data to PDF, CSV, ANDI MS, mzML, or NETCDF file formats