Time-of-Flight Mass Spectrometry
As a venerable pioneer in analytical instrumentation, LECO Corporation has been at the forefront of scientific innovation since 1936. Among our most sophisticated offerings is the time-of-flight (TOF) technology, a cornerstone of modern mass spectrometry. This ingenious method allows for the precise measurement of an ion’s mass-to-charge ratio by determining the time it takes for the ion to travel a known distance.
LECO’s time-of-flight instruments represent the pinnacle of analytical prowess, offering unparalleled speed, sensitivity, and resolution. By harnessing the power of TOF technology, our instruments enable researchers and scientists to unlock the mysteries of complex chemical mixtures with extraordinary accuracy. From environmental analysis to food safety testing, LECO’s TOF systems empower laboratories worldwide to achieve results they can trust, continuing our long-standing tradition of analytical excellence that spans nearly nine decades.
Instrument Solutions for TOF-MS
Application Notes
Learn more with our latest TOF-MS application notes.
- A Comprehensive GC-TOFMS Metabolomics Workflow Early Type 2 Diabetes prediction can be facilitated by the implementation of a metabolomics method for the identification of T2DM biomarkers. A complete automated derivatization workflow is explored.
- Analysis of Fats in Food Products with GC-TOFMS Reporting the fat content of food on packaging material is required for many products. For this reason, the ability to detect and distinguish different types of fats is important. The AOAC has an official method, Method 996.06, for the detection of fats (total, saturated, and unsaturated) that uses GC paired with FID to separate fatty acids, derivatized with methylation.
- Analysis of Heavy Fuel Oil using Multi-Mode Ionization Heavy Fuel Oil Multi-Mode Source MMS GCxGC-HRT4D
- Analysis of Polychlorinated Biphenyls (PCBs) in Fish Oil Supplements by Gas Chromatography with High-Performance Time-of-Flight Mass Spectrometry The American Heart Association recommends eating two servings of fish per week, specifically fish with high fat content such as tuna and salmon. In this study, the advantages of using the Pegasus GC-HRT to analyze complex matrices such as fish oil are highlighted.
- Application of GC High Resolution Time-of-Flight Mass Spectrometry to Mouse Liver Metabolomic Analyses Liver disease affects more than 800 million people worldwide causing at least 1.5 million deaths annually. Mice provided a reliable model for detection of polychlorinated biphenyls associated with non-alcoholic fatty liver disease.
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Videos and Webinars
Watch our most recent videos on TOF-MS.
- Non-Targeted Screening in Food: Boosting Food Analysis using GC×GC-ToF MS Joining us from the University of Messina, Mariosimone Zoccali, Assistant Professor of Analytical Chemistry, present on 'Boosting Food Analysis Using GCxGC-ToFMS. In his talk, Prof. Zoccali explores the pioneering applications of Comprehensive Two-Dimensional Gas Chromatography coupled with Time-of-Flight Mass Spectrometry in the analysis of extra virgin olive oil (EVOO), measured...
- Non-targeted screening in forensics, a discussion of method development and screening of forensic samples using GCXGC-TOFMS Joining us from William and Mary, Dr. Katelynn A. Perrault Uptmor, PI of the Nontargeted Separations Laboratory , present her work of screening samples using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GCXGC-TOFMS) in forensic applications as novel types of evidence appear. Dr. Perrault Uptmor highlights initial approaches to...
- New Dimensions in Non-Targeted Screening of Complex Aroma Profiles Joining us from The Open University, UK, Dr. Geraint Huw Morgan, STEM Research Infrastructure Lead and Director of the Centre for Analytical Solutions, present an in-depth exploration of non-targeted screening techniques for complex aroma profiles. Drawing on his extensive experience in developing advanced methods for volatile organic compounds (VOCs), Dr....
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