LECO Solutions for TOF-MS

As a venerable pioneer in analytical instrumentation, LECO Corporation has been at the forefront of scientific innovation since 1936. Among our most sophisticated offerings is the time-of-flight (TOF) technology, a cornerstone of modern mass spectrometry. This ingenious method allows for the precise measurement of an ion’s mass-to-charge ratio by determining the time it takes for the ion to travel a known distance.

LECO’s time-of-flight instruments represent the pinnacle of analytical prowess, offering unparalleled speed, sensitivity, and resolution. By harnessing the power of TOF technology, our instruments enable researchers and scientists to unlock the mysteries of complex chemical mixtures with extraordinary accuracy. From environmental analysis to food safety testing, LECO’s TOF systems empower laboratories worldwide to achieve results they can trust, continuing our long-standing tradition of analytical excellence that spans nearly nine decades.

Time-of-Flight Mass Spectrometry Application Notes

Learn more with our latest TOF-MS application notes.

• Dual-Detection of Plastics-Derived Pyrolysis Oil

  Data from a single injection of plastics-derived pyrolysis oil using GCxGC with reverse fill-flush modulator and flow splitter is explored.

• GCxGC Coelution Data Detection with RFF Modulator

  Data demonstrating how Paradigm reverse-fill flush modulator and Shift flow splitter enhance GCxGC detection accuracy in fragrance samples.

• Aroma Compounds Pumpernickel Bread

  Aroma Compounds Pumpernickel Bread

• Analysis of Heavy Fuel Oil using Multi-Mode Ionization

  Heavy Fuel Oil Multi-Mode Source MMS GCxGC-HRT4D

• A Comprehensive GC-TOFMS Metabolomics Workflow

  Early Type 2 Diabetes prediction can be facilitated by the implementation of a metabolomics method for the identification of T2DM biomarkers. A complete automated derivatization workflow is explored.

Time-of-Flight Mass Spectrometry Videos

Watch our most recent videos on TOF-MS.

• Non-targeted screening in forensics, a discussion of method development and screening of forensic samples using GCXGC-TOFMS

  Joining us from William and Mary, Dr. Katelynn A. Perrault Uptmor, PI of the Nontargeted Separations Laboratory , present her work of screening samples using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GCXGC-TOFMS) in forensic applications as novel types of evidence appear. Dr. Perrault Uptmor highlights initial approaches to method development for new samples and show recent applications related to chemical profiling of deposited fingermarks, organic gunshot residue and decomposition odor. She also discusses the implications of GCXGC-TOFMS sample visualization in the context of expert testimony for communicating screening processes in forensic casework within the courtroom.
  
  Part of the 2024 Non-Target Screen Webinar Series

• New Dimensions in Non-Targeted Screening of Complex Aroma Profiles

  Joining us from The Open University, UK, Dr. Geraint Huw Morgan, STEM Research Infrastructure Lead and Director of the Centre for Analytical Solutions, present an in-depth exploration of non-targeted screening techniques for complex aroma profiles. Drawing on his extensive experience in developing advanced methods for volatile organic compounds (VOCs), Dr. Morgan highlights innovative approaches and methodologies using advanced technologies like GCxGC-MS, and TOF-MS.
  
  Part of the 2024 Non-Target Screen Webinar Series

• Insights from Liege: Applying Non-Target GCxGC to Enhance Metabolomics Analyses

  Joining us from University of Liège in Belgium, Jef Focant and PH Stefanuto present how the Organic Biological Analytical Chemistry Group utilizes GCxGC-TOFMS in their research. Focant provides a comprehensive overview of testing complex matrices samples, demonstrating the wealth of information that can be gained from analyses across various metabolomics applications. Stefanuto explores the microbiome, offering insight into the using GCxGC-TOFMS to unravel complex samples, paving the way for innovative discoveries.
  
  Part of the 2024 Non-Target Screen Webinar Series